Former Holby star Joe McFadden, whose character Raf Di Lucca died in 2017, tweeted: “Such sad news about the end of #HolbyCity – it kept so many people in work for so long. My thoughts are with friends in the cast and crew”.
EastEnders star Danny-Boy Hatchard tweeted: “Such a shame Holby is coming to an end. Sending big love to all the actors and members of staff who work on the show.”
Earlier this year the BBC announced it would move some of its key departments and staff outside London to make the corporation more reflective of the UK as a whole.
It announced it would launch two new soap-style drama series – one from the North of England and another from one of the nations – over the next three years.
Holby City is filmed in Elstree, Hertfordshire, just outside London.
Leslie Ash, Patsy Kensit, Jane Asher, Robert Powell, Adrian Edmondson, Alex Walkinshaw and Jemma Redgrave are among the stars who have appeared in the show over the years.
In April, EastEnders star Davood Ghadami exited the soap to join Holby City as Eli Ebrahimi, a consultant cardiothoracic surgeon.
He tweeted: “I’ve only had the privilege of being part of @BBCHolbyCity for a couple of months but its already very clear that its a great big family not a workplace.
“It will be sorely missed. Lets go out with a bang.”
Actress Niamh McGrady, who played Mary-Claire Carter until 2015, tweeted that she “can’t believe this news”.
She added: “I’m so incredibly proud of my time on the show and I send so much love to the current cast and crew.
“Holby you will never be forgotten.”